NAT-Net Research Pillar Competitive Grant

About the Grant Program

The NAT-Net Research Pillar Competitive Grant Scheme funds collaborative, NSW-led research projects advancing innovative non-animal technologies in medicine and health.

Up to three grants of $200,000 each were available for two-year projects, with a total funding pool of $600,000.

Eligible teams were required to include at least two research institutions – one based in NSW – and an Early-Mid Career Researcher (EMCR) as Chief Investigator.

The application and selection process ran across two stages: an Expression of Interest, followed by a Full Application for shortlisted teams.

Projects were selected by an independent scientific review panel assessed against criteria including scientific merit, innovation, feasibility, and alignment with NAT-Net’s mission.

Grants were awarded on a competitive basis to researchers and interdisciplinary teams whose work demonstrated both collaboration, scientific excellence and meaningful potential to reduce or replace the use of animals in research, testing, and education.

Successful recipients were announced in May 2026.

Successful Recipients

Dr Alex Mason
Grant Recipient

Dr Alexander Mason

Dr Alexander Mason is a DECRA Fellow and founder of the Synthetic Biomimetic Compartments research group at Molecular Horizons, University…

A/Prof Antoine de Weck
Grant Recipient

A/Prof Antoine de Weck

Associate Professor Antoine de Weck heads THINK (THerapeutic INnovations for Kids) at Children’s Cancer Institute, leading the Computationally Enabled Drug…

Professor Robyn Jamieson
Grant Recipient

Prof Robyn Jamieson

Professor Robyn Jamieson is Head of the Eye Genetics Research Unit at Children’s Medical Research Institute (CMRI), Head of the…

Project: From Static Dosing to Dynamic Guidance: Recreating Developmental Biology Without Animals

Chief Investigator: Dr Alexander Mason
Dr Alex Mason

Institution: University of Wollongong
Funding Awarded: $199,888.00
Duration: May 2026 – May 2028

Research Team

Full NameInstitution
Dr Dzung Do-HaUniversity of Wollongong
A/Prof Ravinash Krishna KumarImperial College London
Prof Mirella DottoriUniversity of Wollongong
Prof Lezanne OoiUniversity of Wollongong

Public Summary

We are developing tiny “smart beads” that can slowly release molecular signals to guide how human stem cells grow and organise into tissues. This will replace current methods that simply flood cells with these signals all at once. By copying how signals behave during human development, our system will help scientists grow more realistic models of the human body in the lab. These models will reduce the need for animal testing and speed up research into health, disease, and new treatments.

What does this research project aim to achieve?

Our goal is to build and test tiny “Active Guidance Beads” that can release growth signals in a controlled way, both in space and over time. Using computer models and experiments, we will design how the beads release their signals and how to place them precisely among human stem cells. We will then grow and test stem-cell cultures to see if these smart beads can create more organised, working tissues. This new tool will help researchers study human biology more directly, without relying on animal models.

Project: Cryptox: In silico prediction of toxicity to splicing modulation therapeutics

Chief Investigator: A/Prof Antoine de Weck
A/Prof Antoine de Weck

Institution: Children’s Cancer Institute
Funding Awarded: $199,523.11
Duration: May 2026 – May 2028

Research Team

Full NameInstitution
Dr Pablo Acera MateosChildren’s Cancer Research Institute
Dr Kieran StocktonMonash University

Public Summary

This project aims to advance a promising new class of RNA-targeted therapies (splicing modulators) by replacing unreliable animal testing with human-specific lab and computational models. These drugs modify how genes are read, but their effects are often missed in animal studies due to species differences. The team will use engineered RNA components and drug analogues to study gene behaviour in human cells, generating data to train a machine learning tool, CrypTox, for predicting toxicity. This approach will improve drug safety and precision, accelerate development, and reduce animal use – positioning NSW as a leader in non-animal testing for RNA-based therapeutics.

What does this research project aim to achieve?

To overcome the limitations of animal testing in splicing modulator discovery, this project will build a human-specific testing pipeline. Aim1 explores whether engineering RNA components (U1 snRNA) can mimic the drug effects of known splicing modulators. Aim2 investigates how changes in drug structure of known drugs affect their impact on gene activity. Aim3 uses the data from the first two aims to improve a computer model called CrypTox, which predicts unwanted side effects. This integrated approach addresses the inadequacy of animal models for the development of splicing modulators – a high growth area of drug discovery.

Project: Accelerating Diagnosis and Treatment in Inherited Retinal Disorders (IRDs) using High-throughput Functional Genomics

Chief Investigator: Prof Robyn Jamieson
Professor Robyn Jamieson

Institution: Children’s Medical Research Institute
Funding Awarded: $200,000.00
Duration: May 2026 – May 2028

Research Team

Full NameInstitution
Dr To Ha LoiChildren’s Medical Research Institute
Dr Benjamin NashSydney Children’s Hospitals Network
Prof Greg NeelyUniversity of Sydney
Dr Nader AryamaneshChildren’s Medical Research Institute
Dr Amin SabriChildren’s Medical Research Institute
Prof John GriggSydney Eye Hospital

Public Summary

Inherited retinal disorders (IRDs) cause progressive vision loss and blindness, yet many patients remain undiagnosed or lack treatment options. This project will use cutting-edge non-animal technologies which combine patient-derived stem-cells differentiated to retinal tissues and high-throughput genetic editing and functional studies, to resolve ambiguous genetic variants and facilitate patient access to clinical trials and therapies. By replacing animal experiments with advanced human-cell systems, the project will accelerate diagnosis, expand genetic therapy opportunities, and create a scalable framework for personalised treatment of retinal diseases, strengthening the leadership of New South Wales in non-animal biomedical innovation.

What does this research project aim to achieve?

Research aim: To determine if high-throughput functional assays can lead to increased diagnostic yield and paths to therapy in inherited retinal disorders (IRDs), using human induced pluripotent stem cell (iPSC)-derived retinal tissues with RPGR-related IRD as the focus project.

Methodology: Creation of a human iPSC line containing prime editor PEmax (Addgene) for pooled editing to introduce pathogenic, benign and VUS variants across RPGR with barcodes for later deconvolution. Optimal guides introduced to transduce iPSC-derived retinal tissues. Pooled edited retinal tissues undergo high throughput protein and single cell transcriptomics to provide cellular-resolution insights to pathophysiology, variant classification and therapy targets.

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